As seen with the inhibition of IKKβ/NF-κB (Figures S2D and S2E), both the silencing of JNK1 and the treatment with SP600125 effectively reversed apoptosis in GADD45β-silenced MM cells (Figures 2D and 2E; Figures S2N–S2P). This evidence concerns the gene MAPK8 and Miyoshi myopathy.