Because this signaling involves the induction of antiapoptotic NF-κB target genes, and we had previously identified the GADD45-family gene, GADD45B, as a transcriptional target of NF-κB encoding a potent and selective inhibitor of the JNK MAPK pathway and, therefore, of apoptosis (De Smaele et al., 2001, Papa et al., 2004), we investigated the involvement of this gene in MM. Here, NFKB1 is linked to Miyoshi myopathy.