NFKB1 and Miyoshi myopathy: Consequently, more than 80% of all primary MM cells and the vast majority of MM cell lines display nuclear accumulation of NF-κB and high NF-κB target gene signature, leading to NF-κB-pathway addiction and sensitivity to apoptosis upon IκBα kinase (IKK) β/NF-κB inhibition (Staudt, 2010).