NFKB1 and cancer: Because the best documented function of NF-κB in cancer is to induce genes that block apoptosis and, despite its ubiquitous nature, NF-κB signaling elicits highly tissue- and context-specific transcriptional programs (DiDonato et al., 2012), we sought to develop a therapeutic approach capable of inhibiting the NF-κB antiapoptotic activity, in a cancer-selective manner.