In contrast, Western diet feeding induced only a modest, non-significant increase in IFN-γ expression in splenic γδT cells of ApoE KO mice (Fig. 3G), and γδT cell IFN-γ expression was similar in wild-type mice that do not develop hypercholesterolemia or aortic lesions after Western diet feeding (Table 1). The gene discussed is APOE; the disease is familial hypercholesterolemia.