At the same time, the 13 PLA2R-Ab positive patients developed a more severe nephrotic syndrome with highest proteinuria levels reaching 10.4±5.7 g/24 h, compared to 5.4±1.9 g/24 h in the 5 PLA2R-Ab negative patients (p = 0.08). Here, PLA2R1 is linked to nephrotic syndrome.