Lin28a siRNA administration decreased IGF1R, Nrf-1, Tfam and p-IRS-1, p-Akt, p-mTOR, p-p70s6k, p-AMPK protein levels while increased Ace-lysine-PGC-1α protein levels in cardiomyocytes underwent H/R injury in HG/HF incubation (Figure 4). This evidence concerns the gene IRS1 and hydrops fetalis.