MMP13 and arthritic joint disease: The result also found that PAR1/PAR3 receptors activation by MMP-13 is increased by thrombin via a mechanism involving EGFR transactivation and activation of PKCδ, c-Src, PI3K, Akt, and finally AP-1 on the MMP-13 promoter, thereby contributing to cartilage destruction during arthritis [60].