For instance, Kauer-Sant'Anna et al. [77] found that the proinflammatory cytokines IL-6 and TNF-α were elevated in both early- (<3 years of disease) and late-stage (>10 years of disease) BD, whereas the anti-inflammatory cytokine IL-10 was increased only in the early stage. The gene discussed is IL10; the disease is Behcet disease.