Analysis of DNA methylation in the CAV1 gene promoter (Figure 2A-C) of RMS cell lines and tumor samples showed hypermethylation in the promoter-associated CpG island in 5 out of 6 ARMS cell lines but in any of the other cell lines used in the experiment nor in the two ARMS tumor samples (Figure 2D-E and Supplementary Figure S1). The gene discussed is CAV1; the disease is neoplasm.