EGFR and lung cancer: Also, we demonstrated that Vav1-depleted H358 lung cancer cells exhibit a 40% reduction in the expression of TGFα, a growth factor that stimulates the Epidermal Growth Factor Receptor (EGFR; [10]) To further expand our knowledge on whether and how Vav1 might be involved in regulating cytokine secretion or other signaling pathways, we performed transcriptome analysis of H358 lung cancer cells in which Vav1 was depleted by siRNA and compared the level of down and up-regulated genes to their expression in control H358 cells (Tables 1 & 2, respectively).