CSF1 and cancer: To examine the effect of CSF1 depletion on lung cancer cell tumorigenicity in an in vivo model, we injected H358 cells treated with either scrambled shRNA (shControl) or with shCSF1 vector (shCSF1) subcutaneously into the flank of athymic NOD/SCID mice and followed the appearance and growth rate of the injected cancer cells.