PLAUR and neoplasm: On these basis, we planned to reconcile our data with the data of literature showing that GM1 promotes angiogenesis [4–6] while GM3 does not, exhibiting an anti-angiogenesis activity under some experimental settings [5], and that uPAR localization in caveolar-LRs is indispensable for an efficient angiogenesis program in EPCs/ECFCs [9,16], commonly considered the main source of vasculogenesis in human tumours [25].