For instances, the peptide T140 and its analogs TC14012 and TN14003 are reported with effective inhibitory roles mainly in lymphocytic leukemia cells, such as pre-B ALL cell line NALM6 and primary cells from pre-B ALL patients16, 17 or B-CLL cells from patients, by down-regulating CXCL12-induced phosphorylation of Erk/MAPK and STAT3 signaling pathway18. The gene discussed is CXCL12; the disease is B-cell chronic lymphocytic leukemia.