Several lines of evidences suggest that it function as a lung-specific tumor suppressor: a) Gprc5a-/- mice develop spontaneous lung tumors[2]; b) loss of heterozygosity of chromosome 12p, where GPRC5A gene (12p12.3-p13) resides, is common in NSCLCs[3, 4]; and c), GPRC5A expression is suppressed in many lung cancer cell lines and tumor tissues compared to adjacent normal lung tissues[2, 5]. Here, GPRC5A is linked to lung carcinoma.