We hypothesized that hBMVEC IL-1β and/or IL-6 were likely responsible for the increase in C6 glioma sCp gene expression when hBMVEC were stimulated apically with LPS as in Figure 5B. To test this, we grew C6 glioma cells either alone (C6) or distal to hBMVEC in transwell (EC/-/C6). Here, IL1B is linked to central nervous system cancer.