Given the well-established role of S100A4 in regulating the expression of so-called metastasis executioners like MMPs, as well as the critical involvement of VEGF-C in regulating cell adhesion, permeability of blood and lymph vessels, and angiogenesis of tumors, NFAT5 is likely involved as a key player in promoting the invasion of breast cancer cells and formation of distal metastases [11],[12]. This evidence concerns the gene S100A4 and breast carcinoma.