Concurrent upregulation of epithelial makers, such as E-cadherin and α-catenin, and downregulation of mesenchymal markers, such as vimentin, β-catenin, and Bmi1 were observed in breast cancer cells upon ablation of NFAT5 or S100A4 (Figure 3D to F). This evidence concerns the gene BMI1 and breast carcinoma.