When the study subjects were classified into obese (obese: BMI ≥ 27 kg/m2) (PCOS n = 72; Control n = 9) and non-obese groups (BMI < 27 kg/m2) (PCOS n = 176; Control n = 83), the non-obese PCOS patients carried significantly higher frequency of IRS-2 Asp/Asp as compared with the control group (p = 0.004) (Table 4). The gene discussed is IRS2; the disease is polycystic ovary syndrome.