When we further investigated the effect of interaction of IRS-1 Gly972Arg and IRS-2 Gly1057Asp on the risk of PCOS, we found that women carried IRS-1 Gly/Arg or IRS-2 Asp/Asp had an increased risk of PCOS (OR = 2.49, 95% C.I. 1.16-5.37, p = 0.019). The gene discussed is IRS2; the disease is polycystic ovary syndrome.