INS and Glucose intolerance: In this study, despite the PCOS subjects were significant younger, with higher risk of morphologic change, glucose intolerance, and endocrine dysfunction than the control subjects (Table 1), we only found increased levels of fasting insulin, and elevated HOMA index in women carrying the homozygous Asp/Asp genotype than their counterpart (Gly/Gly and Gly/Asp) (Table 3).