Insulin resistance, particularly in skeletal muscle and adipose tissue with sensitivity in ovarian tissue, affects up to 70% of women with PCOS and is a risk factor in PCOS women for developing type 2 diabetes [7,8]; however, the mechanisms for defects in insulin signaling in the disorder are complex [9] and have not been fully elucidated. The gene discussed is INS; the disease is type 2 diabetes mellitus.