During myocardial ischemia or reperfusion, the expression of many genes, such as c-fos, c-jun, junB, Egr-1 and HSP70, are upregulated [2], and some of them are considered to be involved in the endogenous cardioprotection against myocardial ischemia-reperfusion injury. The gene discussed is JUNB; the disease is myocardial ischemia.