Aforementioned GWAS have investigated associations of IKZF1 and ARID5B genotypes with treatment outcomes, and Linabery et al. [12] assessed interaction with age and sex demographics; however, we hypothesise that genetic variants compounded with environmental exposures and the developmental stages at which they occur, may contribute to the background of risk in childhood ALL. This evidence concerns the gene ARID5B and acute lymphoblastic leukemia.