Also, a graduated scale of ALL risk was demonstrated for: i) increasing number of risk alleles at four of the loci combined (ARID5A, IKZF1, CEBPE and BMI1-PIP4K2A); and ii) an ARID5B risk allele with odds highest for children younger than five years and lowest for those older than 10 years. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.