Several downstream targets and interaction partners of S100A4 are involved in S100A4-mediated tumor migration and invasion (18), and S100A4 reportedly interacts with multiple molecular proteins involved in the metastatic processes of cytoskeletal rearrangement and cell motility, including F-actin, tropomyosin and the heavy chain of nonmuscle myosin II (18). Here, S100A4 is linked to neoplasm.