Moderate S100A4 overexpression was found in a doxorubicin-resistant colon cancer cell line compared to doxorubicin-sensitive cells (27), whereas S100A4 knockdown was associated with upregulation of BNIP3, increased sensitivity of pancreatic ductal adenocarcinoma cell lines to gemcitabine treatment, and enhanced apoptosis (28). Here, S100A4 is linked to malignant colon neoplasm.