IRAK3 and cancer: During the process of submission the authors have learned that the DFGx specificity mutation described in this study is also observed in multiple cancer kinases including Aurora A, PKCgamma, Haspin, DDR1, ITK, TRKA, IRAK3 and BRAF (Creixell et al. unpublished), suggesting that amino acid changes that occur during evolution are resampled in cancer.