Additionally, high levels of TRPC3 protein are expressed in spontaneously hypertensive rats (SHR), as well as in patients with hypertension, and upregulated TRPC3 increased the Ca2+ influx in SHRs compared with normotensive Wistar-Kyoto rats (WKY) [21]–[24]. The gene discussed is TRPC3; the disease is Hypertension.