One of the major metabolic effects of chronic hypercortisolaemia and a key feature in the development of the metabolic syndrome is insulin resistance (IR), a condition characterized by persistent high levels of peripheral glucose (hyperglycaemia) and insulin (hyperinsulinaemia) due to a reduced ability of insulin to lower blood glucose levels by uptake into muscle tissue (insulin insensitivity) [4]. Here, INS is linked to Insulin resistance.