Using regression models to measure mediation, it was also found in the Atherosclerosis Risk in Communities study (ARIC) that diabetes status, low HDL cholesterol, high BMI, smoking and physical inactivity were important mediators between life course SEP and a score of inflammation which included CRP, von Willebrand fator, fibrinogen, and white blood cell count [20]. This evidence concerns the gene CRP and diabetes mellitus.