Nine (9% of the total cohort, 33% of patients with testing) had laboratory documented immunodeficiencies, including hypogammaglobulinemia (5 patients), transient hypogammaglobulinemia (1), and low IgA (1 patient), low vaccine titers (3), low avidity of anti-pneumococcal antibodies (1), low memory B cells (2), and transiently low T cells [72]. Here, CD79A is linked to agammaglobulinemia.