For example, we recently reported in a rat model of type 1 diabetes that Ang II-mediated elevation in oxidative stress, along with a concomitant decrease in antioxidant levels and increased DNA damage, resulted in major cellular degeneration with the diabetic CC that could be blocked either by preventing the formation of Ang II with an ACE inhibitor or by blocking its effects with an AT1 receptor antagonist [12]. Here, ACE is linked to type 1 diabetes mellitus.