In conclusion, in this study we showed that diabetes-induced abnormal cavernosal vascular reactivity, a marker for DMIED, was accompanied by imbalances in ACE-ACE2, ROCK1, ROCK2, and omega-hydroxylase proteins which could be reversed by 3-week chronic treatment with Ang-(1-7) via activation of its Mas receptor. Here, ACE2 is linked to diabetes mellitus.