Furthermore, since only a relatively short term, 3-week chronic treatment with Ang-(1-7) in animals with preestablished diabetes was effective in reversing DM-induced protein and vascular reactivity changes in the diabetic CC, our study has clinical relevance in suggesting that therapeutic strategies aimed at activating the endogenous ACE2/Ang-(1-7)/Mas receptor signaling pathway for even a short time course may be beneficial in DMIED. Here, ACE2 is linked to diabetes mellitus.