For example, we have shown that Ang-(1-7) treatment opposed Ang II-induced oxidative stress and DNA damage that led to penile tissue degeneration in a rat model of type 1 diabetes [12], whereas acute, ex vivo administration of Ang-(1-7) to diabetic rabbit CC segments was effective in attenuating diabetes or Ang II-induced hyperreactivity suggesting a possible role for Ang-(1-7) in the treatment of DMIED [14]. This evidence concerns the gene ANG and diabetes mellitus.