ANG and familial hypercholesterolemia: Ang-(1-7) has also been shown to normalize the severely depressed erectile function observed in DOCA-salt hypertensive rats by activation of Mas receptor and subsequent NO release [21] and oral delivery of Ang-(1-7) in a cyclodextrin formulation reduced penile fibrosis and improved cavernosal endothelial function in mice with hypercholesterolemia [7].