Importantly, our results showed that chronic 3-week daily treatment with exogenous Ang-(1-7) was able to reverse diabetes-induced changes in ACE1 and ACE2 and vascular reactivity in the rat CC presumably by activation of the endogenous ACE2/Ang-(1-7)/Mas receptor pathway and readdressing of the proposed imbalances in the two counterregulatory branches of the RAAS in the diabetic CC. Here, ACE2 is linked to diabetes mellitus.