K-RAS mutations have been found in approximately 17% of all NSCLC, especially in adenocarcinomas (27%–34%), whereas the discovery of activating mutations in the EGFR gene (23%) and rearrangements of anaplastic lymphoma (ALK) (5%) were found and had also relevant impact in the treatment of lung cancer patient, through their responsiveness to tyrosine kinase inhibitor (TKI) agents, such as erlotinib, crizotinib, and gefitinib [6, 7]. Here, KRAS is linked to lung cancer.