Reporter assays revealed target sequences for mir-19a and mir-19b-1 in the 3′UTR of PTEN [61] and the introduction of mir-19a and mir-19b-1, or the full cluster, was sufficient to induce c-MYC-driven B-cell lymphoma development in mouse model by restoring PTEN expression levels [57, 62]. The gene discussed is PTEN; the disease is B-cell non-Hodgkin lymphoma.