Previous studies performed by our group have shown that the addition of the S. mansoni antigens Sm29, PIII, and TSP-2 in cultured PBMC from cutaneous leishmaniasis patients stimulated with soluble Leishmania antigen (SLA) caused a reduction in the levels of IFN-γ and TNF in a significant number of individuals, with an increase in the levels of IL-10 [9]. The gene discussed is TNF; the disease is cutaneous leishmaniasis.