DNAJB1 and Huntington disease: It was shown that the oral administration of 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) markedly suppressed eye degeneration, inclusion formation, and lethality in a SCA 3 Drosophila model and also neurodegeneration in an HD Drosophila model by induction of HSP70, HSP40, and HSP90 expression [227].