IRF3 and neoplasm: This can indicate that, in response to molecules secreted by CC cells and in particular HPV+ cells, M1 macrophages upregulated the expression of TLR-3, -7, and -9, which could induce nuclear factor kappa-B (NF-κΒ) and Interferon regulatory transcription factor 3 (IRF3) pathway activation, facilitating host defense and tumor cell killing.