Another point to be stressed is that the activation of nitric oxide synthase (iNOS) and cyclooxygenase-2 by TLR signaling resulted in an increase in IL-10 and vascular endothelial growth factor (VEGF) levels, as well as those of TGF-β, favoring the tumor microenvironment by mediating immune suppression [43]. This evidence concerns the gene TGFB1 and neoplasm.