TGFB1 and neoplasm: On the other hand, TH2 cytokines IL-4, IL-13, and IL-10, as well as glucocorticoids, give rise to M2 macrophages, a phenotype characterized by low expression of IL-12 and high expression of IL-10, transforming growth factor-beta (TGF-β), angiogenic factors, high expression of scavenger and mannose and galactose receptors CD163 and CD206, respectively, deficient capacity as antigen-presenting cells, low antitumor activity, and an increase in the ability to support angiogenesis and tissue remodeling, facilitating tumor growth and invasion [8, 9].