While monoclonal antibodies to vascular endothelial growth factor (VEGF) (bevacizumab) and the extracellular domain of epidermal growth factor receptor (EGFR) (cetuximab, panitumumab) are already established in treatment of advanced CRC [2], the application of small molecule kinase inhibitors (SMI) is still largely restricted to clinical trials. This evidence concerns the gene EGFR and colorectal carcinoma.