Here we have analyzed and compared the biological and molecular effects of four molecular cancer therapeutics, the multikinase inhibitor regorafenib [3], the inhibitor of the V600E/V600K mutant form of BRAF vemurafenib [17], the selective MEK1/MEK2 inhibitor trametinib [18], and the AKT inhibitor perifosine [19], in CRC cells in order to elucidate determinants of their efficiency or inefficiency. Here, AKT1 is linked to cancer.