As negative modulation of miR-1 is in agreement with its tumor-suppressive role in prostate cancer cells, modulating at least indirectly the expression of AR and consequently their proliferative capabilities [73], downregulation of miR-133b does not reflect recent reports in which its dependence on androgen receptor and its role in maintaining cell viability is described [74, 75]. This evidence concerns the gene AR and prostate carcinoma.