Alteration of the miR-15a and miR-16-1 translates into multiple tumor-promoting processes through the derepression of key cell cycle-and apoptosis-related genes such as B-cell CLL/lymphoma 2 (BCL2), wingless-type MMTV integration site family-member 3A (WNT3A) and cyclin D1 (CCND1) [97]. The gene discussed is WNT3A; the disease is neoplasm.