Notably, in L. (L.) amazonensis infection, a peaking of lysozyme+ cells was observed at 60 days PI and a significant number of stained cells were also observed at 90 days PI compared to L. (V.) braziliensis infection; however, L. (V.) braziliensis infection showed a persistence of lysozyme+ cells during the evolution of infection, with a higher density at 120 days PI compared to L. (L.) amazonensis infection (P < 0.05). The gene discussed is LYZ; the disease is infection.