JAG1 and pancreatic neoplasm: A role in EMT has also been described in cervical cancer, where JAG1 expression correlates with the rapid induction of phosphoinositol-3-kinase (PI3K)-mediated EMT (67); in hepatocellular carcinoma where it is repressed by the tumor-suppressor RUNX3 (68); and in treatment-resistant pancreatic cancer cells, where the JAG1-Notch2 axis controls several EMT transcription factors such as SNAIL, SLUG, and ZEB1 (69).