Stromal JAG1-induced Notch activation also mediated the tumor invasion and intravasation caused by the deletion of metastasis-suppressor gene Aes (Grg5) in ApcΔ716 intestinal polyposis mice, suggesting that JAG1-induced Notch signaling can be a promising target for prevention and treatment of colon cancer metastasis (93). This evidence concerns the gene JAG1 and malignant colon neoplasm.