For example, it can directly regulate the cell cycle and induce proliferation by inducing cyclin D1 in breast cancer (74), cyclin D1, cyclin E, and c-Myc in colon cancer (73), or by promoting CDK2 kinase activity while repressing the p27 cell cycle suppressor in prostate cancer cells (75). The gene discussed is CCND1; the disease is malignant colon neoplasm.