ALK and non-small cell lung carcinoma: In a phase III second-line NSCLC trial of patients with ALK-rearranged tumors randomized to receive crizotinib vs. chemotherapy with docetaxel or pemetrexed, an ORR = 65% was demonstrated, as well as a PFS benefit of 4.7 months vs. chemotherapy (7.7 vs. 3.0 months, HR 0.49, p < 0.001) (48).