FN1 and neoplasm: Thus, the ability of PCLP1 to potentiate cell binding to fibronectin through the activation of integrins could increase the interaction of platelets with tumor cells, fibronectin acting as a bridge molecule between αvβ3 or αvβ5 expressed on tumor cells and αIIbβ3, αvβ3, and α5β1 integrins expressed on platelets.