On the other hand, a 20% electroporation-mediated transient upregulation of CPT1b in the distal hind limb muscles is sufficient to improve HFD-induced insulin resistance in rats via attenuating triacylglycerol content, the membrane-to-cytosolic ratio of diacylglycerol, and protein kinase Cθactivation [15]. Here, CPT1B is linked to Insulin resistance.