This review aims to delineate the profile of several notable adipokines implicated in obesity and obesity-related metabolic disorders, which includes leptin, adiponectin, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), plasminogen activator inhibitor-1, visfatin, and chemerin, whilst exploring their therapeutic role against obesity. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.