A subsequent SIRS and multiple-organ dysfunction syndrome developed with abrupt increases in C-reactive protein (CRP—Figure 1(a)), leukopenia followed by leukocytosis (Figure 1(b)), hypothermia (<36°C), metabolic acidosis, hyperlactatemia, need of vasopressors in high doses, mechanical ventilation, and increases in serum creatinine (sCr) (Figure 2(a)).Urine output was maintained with loop diuretic administration (Figure 2(b)). The gene discussed is CRP; the disease is Increased total leukocyte count.