One could take advantage of this improved retention when pre-coating NP with albumin in cancer therapy as specific factors account for the accumulation of this protein in solid tumors: a decreased level of HSA in cancer patients, inducing a need for albumin digestion to cover the need in amino acids for tumor growth and the presence of two albumin receptors, gp60 in tumor endothelium and SPARC in tumor interstitium [75]. This evidence concerns the gene SPARC and cancer.