The fasting plasma insulin levels and BMI age- and sex-specific percentiles are also independent risk factors for T2D (odds ratio = 1.066, 95% CI: 1.001–1.135, and P = 0.045 for fasting insulin; odds ratio = 1.047, 95% CI: 1.014–1.080 for BMI age- and sex-specific percentiles, and P = 0.004, resp). This evidence concerns the gene INS and type 2 diabetes mellitus.