Huang et al. (2009) have described that CYP39A1 may be hypermethylated in ovarian cancer, but did not report effects on mRNA levels. Using a hypomorphic DNMT1 mouse line, Kutay et al. (2012) recently reported that the expression change in the liver of Cyp39a1 in response to alcohol challenge was blunted by more than half in the DNMT1 deficient lineage. The gene discussed is DNMT1; the disease is ovarian cancer.