NFKB1 and neoplasm: DAMP activation of TLRs expressed on tumor cells initiates cascades that mediate the release of cytokines and chemokines from the tumor cells which, in turn, recruit immune cells leading to upregulation of NF-κB signaling and subsequent release of additional cytokines, pro-angiogenic mediators, growth factors, and anti-apoptotic proteins that continue to promote tumor survival and progression (15, 20, 27).