Acetylsalicylic acid has been shown to reduce the long-term risk of developing some cancers, and, while the precise mechanisms of action remain uncertain, there is evidence that modulation of the NF-κB signal transduction pathway by aspirin and other non-steroidal anti-inflammatory agents is an important mechanism in inducing apoptosis in neoplastic epithelial cells (59, 60). Here, NFKB1 is linked to cancer.