IFNG and infection: Despite the antiviral effects of type I IFNs, and in the context of the antibacterial effects of IFNγ, it is increasingly evident that host responsiveness to type I IFNs correlates with increased host susceptibility to infections by L. monocytogenes, M. tuberculosis, Francisella tularensis, and several other intracellular bacterial pathogens (22–24).