In the same study, a CD4+FOXP3-CD45RO+ T cell population co-producing IFN-γ and IL-10 was more prevalent among children with uncomplicated malaria than those with severe disease, suggesting a beneficial immunoregulatory role for this IL-10 producing subset, presumably by limiting excessive inflammation (Walther et al., 2009). This evidence concerns the gene FOXP3 and malaria.