Moreover, HA synthases (HAS1 and 2) and HYALs (HYAL1 and 2) protein expression was increased in inflammatory cells from both stroke and peri-infarcted regions of the brain, with HYAL1 upregulated in microvesssels and intracellularly in neurons, while HAS2 became translocated into the nuclei of neurons in peri-infarcted areas (39). This evidence concerns the gene HYAL1 and Stroke.