The first study looking at functional aspects of the expression of ODAM in tumors has shown that it can inhibit tumorigenic characteristics in the human breast cancer cell line MDA-MB-231 in vitro and the transplantation of ODAM-expressing tumor cells into mice lead to significantly reduced tumor growth and their inability to metastasize, compared to control cells that did not express ODAM (Kestler et al., 2011). This evidence concerns the gene ODAM and breast cancer.