Indeed, pre-clinical studies that have treated skinned muscle fibers with oxidants have shown that oxidative modification of myofilament proteins reduces tension, velocity, myosin ATPase/XB kinetics and strongly-bound XBs (Wilson et al., 1991; Galler et al., 1997; Perkins et al., 1997; Callahan et al., 2001; Heunks et al., 2001; Coirault et al., 2007), effects that resemble the myofilament functional phenotype we observe in cancer patients (Toth et al., 2013). Here, TNXB is linked to cancer.