Considering that experimental parkinsonism induces a large increase in astrocytic volume and that astrocytes are organized into functional networks through interconnection via intercellular GJs composed of Cx (Giaume and Mccarthy, 1996; Nagy et al., 1999; Dermietzel et al., 2000), we sought to determine if expression pattern and density of Cx30 and Cx43 connexins were affected by DA depletion. This evidence concerns the gene GJA1 and Parkinson disease.