The improvement in the 3xTg-AD mice both in terms of their Tau pathology and their behavior, reinforces and extends several reports on the beneficial effects of clearing hyperphosphorylated Tau (Alvarez et al., 1999; Zheng et al., 2002, 2005, 2010; Wang et al., 2003; Zhang et al., 2004, 2013; Wen et al., 2007; Piedrahita et al., 2010; Castro-Alvarez et al., 2011; Crews et al., 2011). Here, MAPT is linked to Alzheimer disease.