GRN and Pick disease: A study indicated substantial FA reduction in the fornix of the behavioral variant FTD that correlated with memory decline (Hornberger et al., 2012), and other studies have indicated that the fornix is affected in Pick’s disease, FTD with tau mutation, or TAR-DNA-binding protein-43 type C pathology, but not for FTD caused by a progranulin mutation or with fused-in-sarcoma protein accumulation (Rohrer et al., 2011; Hornberger et al., 2012).