MME and Alzheimer disease: Several other experimental strategies, aimed at increasing NEP within the CNS, by targeting either the CNS directly, or via the periphery, have suggested that upregulation of NEP might be used to treat AD (Iwata, 2003; Marr et al., 2003, 2004; El-Amouri et al., 2008; Spencer et al., 2008, 2011; Briyal et al., 2011).