In irritable bowel syndrome (IBS), which is characterized by chronic recurrent abdominal pain, disorder of brain-gut function may be associated with corticotropin-releasing hormone (CRH) and/or serotonin, since administration of CRH exacerbates the visceral sensorimotor response, whereas inhibition of CRH or serotonin with their respective antagonists or antidepressants is protective (Fukudo, 2013). The gene discussed is CRH; the disease is irritable bowel syndrome.